No effect of polymorphisms in catechol-O-methyltransferase was observed to get linked with postoperative oxycodone use. The pharmacodynamics of oxycodone is generally dependent on polymorphic enzymes CYP2D6 and CP3A. You could just take these painkillers for a brief timeframe soon after surgical procedures or an harm just like a damaged bone. https://wockusa.com/product-category/codeine/