A hallmark of the G1/S transition in budding yeast cell cycle is the proteolytic degradation of the B-type cyclin-Cdk stoichiometric inhibitor Sic1. Deleting SIC1 or altering Sic1 degradation dynamics increases genomic instability. Certain key facts about the parts of the G1/S circuitry are established: phosphorylation of Sic1 on multiple sites is necessary for its destruction. and bo... https://www.jmannino.com/great-pick-Sophie-Allport-Zebra-Made-to-Measure-Blackout-Roller-Blind-Soft-Grey-Blue-top-super/